Tyk2-IN-22
Tyk2-IN-22 (Compound A8) is a potent and selective Tyk2 inhibitor with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM for Tyk2, JAK1, and JAK3, respectively, and it suppresses STAT5 phosphorylation. This small molecule is a valuable research tool for investigating JAK-STAT signaling pathways in autoimmune and inflammatory disease models, both in vitro and in vivo.
Product Specifications
CAS Number
933667-23-3
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1C=C (N=C2NC (=NN12) C=3C=CC (Cl) =CC3) CN4CCOCC4
Molecular Formula
C16H16ClN5O2
Molecular Weight
345.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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