5-HT6 inverse agonist 1
Compound 33 is a potent 5-HT6 receptor inverse agonist (Ki=23 nM, Kb=6.62 nM) . It inhibits downstream Cdk5 and mTOR signaling in vitro and demonstrates in vivo efficacy by alleviating tactile allodynia in a rat model of neuropathic pain following spinal nerve ligation.
Product Specifications
CAS Number
2727088-38-0
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Smiles
Cl.O=C (NC1CCNCC1) C=2C=CN (C2C=3C=CC (F) =CC3) S (=O) (=O) C=4C=CC=C (Cl) C4
Molecular Formula
C22H22Cl2FN3O3S
Molecular Weight
498.4
Storage Conditions
-20°C
Notes
For research use only.
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