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WRN inhibitor 16

WRN inhibitor 16 (Example 83) is an orally bioavailable small molecule targeting the Werner syndrome helicase. In preclinical studies using a SW48 colorectal cancer xenograft model, it demonstrated inhibitory activity but did not induce tumor regression. This tool compound is useful for investigating WRN's role in DNA repair and microsatellite unstable cancers.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Molecular Formula

C31H30F4N4O5S

Molecular Weight

646.65

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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