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SOS1-IN-17

SOS1-IN-17 (Compound 8d) is a potent, orally bioavailable SOS1 inhibitor that disrupts the SOS1-KRASG12C interaction (IC50 = 5.1 nM) . It effectively inhibits ERK phosphorylation and cellular proliferation in KRASG12C-mutant cancer cells and demonstrates in vivo antitumor activity in pancreatic cancer mouse models.

Product Specifications

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Molecular Formula

C29H34F3N5O2

Molecular Weight

541.61

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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