ZZ151
ZZ151 is a potent and selective SOS1 PROTAC degrader that exhibits strong anti-proliferative activity in KRAS-mutant cancer cell lines and demonstrates superior in vivo efficacy in murine xenograft models harboring KRASG12D and G12V mutations.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C ([C@H]1N (C ([C@@H] (NC (CCCCCC (N2CCC (C3=CC4=C (N[C@@H] (C5=CC (C (F) (F) F) =CC (N) =C5) C) N=C (C) N=C4C=C3OC) CC2) =O) =O) C (C) (C) C) =O) C[C@H] (O) C1) N[C@H] (C6=CC=C (C7=C (C) N=CS7) C=C6) C
Molecular Formula
C54H68F3N9O6S
Molecular Weight
1028.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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