BTX6654
BTX-6654 is a cereblon-directed SOS1 PROTAC degrader that inhibits proliferation in KRAS-mutant cells by downregulating pERK and pS6 signaling. It serves as a chemical probe for studying SOS1-dependent oncogenic pathways in both cellular and in vivo cancer models.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
FC (F) (F) C1=C (C) C ([C@@H] (C) NC2=NN=C (C) C3=CC=C (N4CCN (C (C5CCN (C (CCN6CCC (C7=CC (CN (C8CCC (NC8=O) =O) C9=O) =C9C=C7F) CC6) =O) CC5) =O) CC4) C=C32) =CC=C1
Molecular Formula
C50H57F4N9O5
Molecular Weight
940.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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