NSC 12
NSC 12 is an orally bioavailable pan-FGF inhibitor that traps FGF ligands, blocking FGFR1 signaling and disrupting tumor-promoting ternary complex formation without affecting heparin binding. It demonstrates antitumor activity by inhibiting cancer cell proliferation, angiogenesis, and metastasis in both cellular assays and animal models.
Product Specifications
CAS Number
102586-30-1
Product Name Alternative
NSC 12, NSC12, NSC-12
Field of Research
Cardiovascular Research, Neuroscience, Signal Transduction
Purity
99.51% (May vary between batches)
Solubility
DMSO:8 mg/mL (16.51 mM) ; Ethanol:PBS (pH 7.2) (1:2) :Insoluble; Ethanol:8 mg/mL (16.51 mM) ; DMF:8 mg/mL (16.51 mM)
Smiles
C[C@@]12[C@] ([C@]3 ([C@@] ([C@]4 (C) C (=CC3) C[C@@H] (O) CC4) (CC1) [H]) [H]) (CC[C@@]2 ([C@H] (CC (C (F) (F) F) (C (F) (F) F) O) O) [H]) [H]
Molecular Formula
C24H34F6O3
Molecular Weight
484.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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