Dapolsertib
Dapolsertib (SEL24-B489) is an orally active, dual inhibitor of PIM kinases and FLT3-ITD. It reduces substrate phosphorylation and triggers apoptosis in leukemia cells in a dose-dependent manner. This compound is utilized in oncology research, showing activity in both cellular assays and in vivo models of hematological malignancies.
Product Specifications
CAS Number
1616359-00-2
Product Name Alternative
SEL-24-B489, SEL24-B489, SEL24-B-489, SEL 24-B489, SEL24 B489, SEL24-B 489, SEL24B489, MEN1703, MEN 1703
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
99.61% (May vary between batches)
Solubility
DMSO:15 mg/mL (33.62 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM)
Smiles
O=N (=O) C=1C (Br) =C (Br) C=C2C1N=C (N2C (C) C) C3CCNCC3
Molecular Formula
C15H18Br2N4O2
Molecular Weight
446.14
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
PPAN, CT (PPAN, BXDC3, SSF1, Suppressor of SWI4 1 homolog, Brix domain-containing protein 3, Peter Pan homolog) (AP)