Trioxacarcin A
Trioxacarcin A is a natural product alkylating agent that selectively targets and alkylates flexible guanine residues within parallel G-quadruplex (G4) DNA loops, such as those in the RET oncogene, thereby stabilizing these structures. This mechanism supports its investigation as a novel antitumor compound in biochemical and cellular studies targeting G4-DNA.
Product Specifications
CAS Number
81552-36-5
Smiles
O ([C@]12[C@]3 ([C@]4 (C (OC) OC) O[C@]1 ([C@@] (O4) (C=5C (O2) =C6C (=CC5C) C (OC) =C7C (=C6O) C (=O) [C@@H] (O) C[C@@H]7O[C@H]8C[C@@] (C) (O) [C@H] (OC (C) =O) [C@H] (C) O8) [H]) [H]) CO3) [C@H]9C[C@@H] (O) [C@] (C (C) =O) (O) [C@H] (C) O9
Molecular Formula
C42H52O20
Molecular Weight
876.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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