Elesclomol

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis) . Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].

Product Specifications

CAS Number

[488832-69-5]

Product Name Alternative

STA-4783

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Apoptosis; Cuproptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Elesclomol.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(C1=CC=CC=C1)N(NC(CC(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C

Molecular Formula

C19H20N4O2S2

Molecular Weight

400.52

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Kirshner JR, et al. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther. 2008 Aug;7 (8) :2319-27.|[2]Bair JS, et al. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. J Am Chem Soc. 2010 Apr 21;132 (15) :5469-7|[3]Liam M Guthrie, et al. Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Science. 2020 May 8;368 (6491) :620-625.|[4]Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375 (6586) :1254-1261.|[5]Peter Tsvetkov, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul;15 (7) :681-689.