DD205-291
DD205-291 is an orally bioavailable PROTAC that potently degrades HPK1 (DC50 = 5.3 nM) . It suppresses SLP-76 phosphorylation and enhances cytokine production, including IL-2 and IFN-γ, making it a valuable tool for studying T-cell signaling and immune oncology in both cellular and animal models.
Product Specifications
CAS Number
3047066-15-6
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1NC (=O) CCN1C2=CC (=CC=C2Cl) C (=O) N3CCC (CC3) CC4CCN (C5=NC=C (C=C5) C6=NC7=C (N=C6) NC=C7C=8C=NN (C8) CC (F) (F) F) CC4
Molecular Formula
C38H38ClF3N10O3
Molecular Weight
775.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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