ATM Inhibitor-11
ATMInhibitor-11 (Compound 1) is a potent, brain-penetrant ATM kinase inhibitor with single-digit nanomolar IC50 values against ATM and KAP1 phosphorylation. It demonstrates favorable in vivo exposure and has shown antitumor efficacy in NCI-H441 xenograft models, supporting its use in oncology research, particularly for studying DNA damage response pathways.
Product Specifications
CAS Number
2878473-51-7
Field of Research
Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1N (C=2C=NC=3C=C (F) C (=CC3C2N1C (C) C) C=4C=NC (OCCCN5CCN (C) CC5) =CC4) C
Molecular Formula
C27H33FN6O2
Molecular Weight
492.59
Storage Conditions
-20°C
Notes
For research use only.
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