DNA crosslinker 6

DNA crosslinker 6 (compound 1) is a potent anti-mitotic agent that selectively targets AT-rich DNA sequences, disrupting AT-hook protein binding (IC50=0.03 μM) . It also demonstrates anti-protozoal efficacy against Trypanosoma brucei (EC50=0.83 μM), making it a valuable tool for studying DNA-protein interactions and parasitic diseases in biochemical and cellular assays.