PROTAC BRM/BRG1 degrader-2
PROTAC BRM/BRG1 degrader-2 (Example.004) is a highly effective small molecule that potently degrades BRM/BRG1 ATPases, demonstrating a DC50 below 10 nM and an IC50 of 15 nM in A549 cell assays. This tool compound is valuable for in vitro research targeting chromatin remodeling and transcriptional regulation in oncology and epigenetics.
Product Specifications
CAS Number
2933124-32-2
Field of Research
Epigenetics & Chromatin, Neuroscience; Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
NC=1C=2C (N (N1) C3CCN (CC3) C=4N=CC (=CN4) [C@H]5CC[C@H] (C (N[C@H] (C (=O) N6[C@H] (C (N[C@@H] (C) C7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) [C@@] (C) (C) C) =O) CC5) =CC (=NN2) C9=C (O) C=CC=C9
Molecular Formula
C50H60N12O5S
Molecular Weight
941.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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