PROTAC HIF-1α degrader-1

PROTAC HIF-1α degrader-1 (V2) is a potent small molecule that selectively degrades HIF-1α with an IC50 of 7.54 μM. It demonstrates anti-proliferative effects, reduces HIF-1α protein levels, and induces apoptosis in cellular models, supporting its use in cancer and hypoxia-related disease research.