EGFR/VEGFR2-IN-3
EGFR/VEGFR2-IN-3 (compound 9) is a dual inhibitor of EGFR and VEGFR-2 with IC50 values of 0.129 μM and 0.142 μM, respectively, and shows weaker activity against COX-2. This small molecule induces apoptosis and G2/M phase cell cycle arrest in vitro, supporting its investigation in oncology research for anti-angiogenic and anti-proliferative effects.
Product Specifications
CAS Number
710972-61-5
Field of Research
Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction
Smiles
O=C (NNC (=S) NC1=CC=C (C=C1) C) CSC2=NC=3C=CC=CC3C (=O) N2C4=CC=C (Cl) C=C4
Molecular Formula
C24H20ClN5O2S2
Molecular Weight
510.03
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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