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TGase2-IN-1

TGase2-IN-1 (Compound 22) is an orally bioavailable (74.6%) TGase2 inhibitor with an IC50 of 1.12 μM, demonstrating potent activity (IC50 0.07 μM) in human retinal endothelial cells. It effectively reduces retinal vascular leakage in a Streptozotocin-induced diabetic mouse model, supporting research in diabetic retinopathy and vascular biology.

Product Specifications

CAS Number

2244702-64-3

Field of Research

Protein Biochemistry

Smiles

O=C1C=C (N) C (=O) C2=NC (=CC=C12) C=3C=CC (OC4CCN (CC4) C (C) C) =CC3

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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