EGFR-IN-132
EGFR-IN-132 is a potent and orally bioavailable EGFR inhibitor targeting multiple mutations, including L858R/T790M and C797S resistance variants, with IC50 values in the sub-nanomolar range. It is a valuable research tool for studying resistance mechanisms and evaluating antitumor efficacy in both cellular and animal models of non-small cell lung cancer.
Product Specifications
CAS Number
2809982-20-3
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C[C@H]1CN2C=3C (NC2=NC (=O) C=4C=C (C5=C (OCCC1) N (C) N=C5) N=C (C) C4) =CC (NC6COC6) =CC3
Molecular Formula
C27H31N7O3
Molecular Weight
501.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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