SMER28

SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Product Specifications

CAS Number

[307538-42-7]

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SMER28.html

Purity

99.92

Solubility

DMSO : ≥ 32 mg/mL

Smiles

C=CCNC1=C2C=C(Br)C=CC2=NC=N1

Molecular Formula

C11H10BrN3

Molecular Weight

264.12

Precautions

H315, H318, H335

References & Citations

[1]Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285 (15) :11061-7.|[2]Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60 (3) :173-85.|[3]Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25 (6) :1934-42.|[4]Nekova TS, et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/Bpreferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167 (2) :272-4.|[5]Koukourakis MI, et al. SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy. Invest New Drugs. 2018 Oct;36 (5) :773-781.