PROTAC SMARCA2 degrader-28
PROTAC SMARCA2 degrader-28 (Compound 158) is a highly potent, cell-permeable degrader of the SMARCA2 (BRM) protein, demonstrating a DC50 of 3 nM in HiBiT-tagged A549 lung cancer cells. This tool compound enables the study of SMARCA2 biology and its therapeutic potential in oncology research, both in vitro and in vivo.
Product Specifications
CAS Number
2641510-88-3
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C (C (F) (F) F) O.O=C1C2=CC=C (N3CCC (CC3) C (N4CCN (CC4) CC5=CC (N6C7CN (CC6CC7) C8=C (N) N=NC (C9=CC (F) =CC=C9O) =C8) =CC=C5) =O) C=C2C (N1C%10C (NC (CC%10) =O) =O) =O.O=C (C (F) (F) F) O
Molecular Formula
C50H51F7N10O10
Molecular Weight
1084.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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