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PROTAC K-Ras Degrader-5

Compound 69 is a cereblon-recruiting PROTAC that potently degrades pan-KRAS isoforms with a DC50 below 100 nM. This degrader demonstrates anticancer activity and serves as a valuable chemical tool for investigating KRAS biology in both cellular and in vivo cancer models.

Product Specifications

CAS Number

3052745-16-8

Field of Research

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Smiles

O=C1C2=CC=C (C (F) =C2CN1C3C (=O) NC (=O) CC3) N4CCC (CN5CCC (CC5) CC6CCN (CCOC7=NC8=C (F) C (=NC=C8C (=N7) N9CC%10NC (C9) CC%10) C=%11C=C (O) C=C%12C=CC (F) =C (C#C) C%12%11) CC6) CC4

Molecular Formula

C57H63F3N10O5

Molecular Weight

1025.17

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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