PROTAC K-Ras Degrader-5
Compound 69 is a cereblon-recruiting PROTAC that potently degrades pan-KRAS isoforms with a DC50 below 100 nM. This degrader demonstrates anticancer activity and serves as a valuable chemical tool for investigating KRAS biology in both cellular and in vivo cancer models.
Product Specifications
CAS Number
3052745-16-8
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C2=CC=C (C (F) =C2CN1C3C (=O) NC (=O) CC3) N4CCC (CN5CCC (CC5) CC6CCN (CCOC7=NC8=C (F) C (=NC=C8C (=N7) N9CC%10NC (C9) CC%10) C=%11C=C (O) C=C%12C=CC (F) =C (C#C) C%12%11) CC6) CC4
Molecular Formula
C57H63F3N10O5
Molecular Weight
1025.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![LOX Rabbit Monoclonal Antibody [KD Validation]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
CAU24024-01 100 µL
Mitochondrial Transcription Termination Factor (MTERF) Polyclonal Antibody
Sign In for Pricing
View Details CAU24024-02 200 µL
Mitochondrial Transcription Termination Factor (MTERF) Polyclonal Antibody
Sign In for Pricing
View Details 
18629114 3x 1.0 µg
Dsg3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details