EGFR-IN-133
EGFR-IN-133 (Compound 24) is a potent, orally bioavailable EGFR inhibitor effective against wild-type and multiple resistant mutations, including L858R/T790M and C797S variants, with IC50 values in the sub-nanomolar range. It is a valuable research tool for in vitro and in vivo studies exploring resistance mechanisms and therapeutic strategies in non-small cell lung cancer.
Product Specifications
CAS Number
2809982-26-9
Field of Research
Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Signal Transduction
Smiles
FC1=C2N3C (NC2=CC (N[C@@H]4CCOC4) =C1) =NC (=O) C=5C=C (C6=C (OCCC[C@@H] (C) C3) N (C) N=C6) N=C (F) C5
Molecular Formula
C27H29F2N7O3
Molecular Weight
537.56
Storage Conditions
-20°C
Notes
For research use only.
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