PROTAC K-Ras Degrader-6
Compound 102 is a cereblon-based PROTAC that potently degrades pan-KRAS isoforms with a DC50 below 100 nM. This degrader demonstrates anticancer activity and is a valuable tool for investigating KRAS-driven cancers in both in vitro and in vivo research models.
Product Specifications
CAS Number
3052745-46-4
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1NC (=O) C (N2C (=O) N (C3=CC (=CC=C32) N4CCC (CN5CCC (CC5) CC6CCN (CCOC7=NC8=C (F) C (=NC=C8C (=N7) N9CC%10NC (C9) CC%10) C=%11C=C (O) C=C%12C=CC (F) =C (C#C) C%12%11) CC6) CC4) C) CC1
Molecular Formula
C57H65F2N11O5
Molecular Weight
1022.19
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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