6-Demethoxytangeretin

6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons[1][2].

Product Specifications

CAS Number

[6601-66-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Anaplastic lymphoma kinase (ALK) ; ERK; Interleukin Related; JAK; JNK; p38 MAPK; STAT

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/6-demethoxytangeretin.html

Purity

99.37

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=CC(OC)=C13

Molecular Formula

C19H18O6

Molecular Weight

342.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37 (5) :871-6. Epub 2014 Feb 5.|[2]Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna) . 2013 Oct;120 (10) :1397-409.