Acid-degradable Anionic Lipid (ADA)
ADA (Acid-Degradable Anionic Lipids) is revolutionizing mRNA delivery with its unique azido-acetal linker, enabling rapid hydrolysis in endosomes (pH ~6.0) . This breakthrough technology ensures efficient endosomal escape, significantly enhancing mRNA delivery to target cells. ADA-LNPs excel in delivering mRNA to the spleen and liver, making them ideal for immune-related therapies.By degrading into biocompatible byproducts, ADA minimizes long-term tissue persistence and toxicity.ADA-LNPs outperform traditional LNPs, delivering mRNA more effectively to immune cells like macrophages and B cells.
Product Specifications
Field of Research
Metabolism Research
Purity
>95%
Smiles
[Li]OC (=O) C1=C (C (=O) NCCOC (OCCNC (=O) O[C@H]2CC[C@@]3 (C) C (=CC[C@@H]4[C@@H]3CC[C@@]3 (C) [C@H]4CC[C@@H]3[C@H] (C) CCCC (C) C) C2) C2=CC=C (N3N=N3) C=C2) C=C (C (=O) O[Li]) C (C (=O) O[Li]) =C1
Molecular Formula
C49H62Li3N5O 11
Molecular Weight
917.88
Notes
For research use only.
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