HEC96719
HEC96719 is a tricyclic farnesoid X receptor agonist (FXR agonist) for treatment of non-alcoholic steatohepatitis. HEC96719 exhibits excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation. It also shows higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine. Preclinical data on pharmacokinetic properties, efficacy, and safety profiles overall indicate that HEC96719 is a promising drug candidate for NASH treatment.
Product Specifications
CAS Number
2181834-03-5
Purity
0.98
Smiles
ClC1C=CC=C (C=1C1C (COC2C=CC3=C (C4 (CC5C=CC (C (=O) O) =CC=5O3) CC4) N=2) =C (C2CC2) ON=1) Cl
Molecular Formula
C29H22Cl2N2O5
Molecular Weight
549.404
Notes
For research use only.
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