PROTAC SMARCA2 degrader-31
PROTAC SMARCA2-degrader-36 (compound 38) is a potent and selective degrader of the SMARCA2 (BRM) protein, achieving >99% degradation at 100 nM in H929 multiple myeloma cells. This tool compound demonstrates robust antiproliferative effects in vitro and is utilized in cancer research to probe SMARCA2-dependent biology and therapeutic vulnerabilities.
Product Specifications
CAS Number
2380274-45-1
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (CCCCCCCCCC (=O) N1CCN (CC1) C=2C=C (N=NC2N) C3=C (O) C=CC=C3) =O) [C@] (C) (C) C) (=O) N4[C@H] (C (N[C@@H] (C) C5=CC=C (C=C5) C6=C (C) N=CS6) =O) C[C@@H] (O) C4
Molecular Formula
C48H65N9O6S
Molecular Weight
896.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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