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A-889425

A-889425 is a potent and selective oral TRPV1 antagonist, demonstrating species-dependent IC50 values of 34 nM (human) and 335 nM (rat) . It exhibits central nervous system penetration and has been shown in vivo to alleviate mechanical allodynia and spinal neuron hyperexcitability in rat models of inflammatory pain.

Product Specifications

CAS Number

1072921-02-8

Field of Research

Pharmacology & Drug Discovery

Smiles

O=C (NC1=CC=C (C=C1) S (=O) (=O) C (F) (F) F) C2=CCN (C3=NC=CC=C3C) CC2

Molecular Formula

C19H18F3N3O3S

Molecular Weight

425.42

Storage Conditions

-20°C

Notes

For research use only.

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