FXR/CES2 modulator 1
Compound LE-77 (FXR/CES2 modulator 1) is a dual-acting small molecule that activates the farnesoid X receptor (FXR) while inhibiting carboxylesterase 2 (CES2) . This activity has been shown in research to reduce the intestinal toxicity associated with the chemotherapeutic agent irinotecan in experimental models.
Product Specifications
CAS Number
3004676-87-0
Field of Research
Immunology & Inflammation, Metabolism Research
Smiles
O=C (O) COC=1C=CC (=CC1) C2=CC=C (OCC=3C (=NOC3C4CC4) C=5C (Cl) =CC=CC5Cl) C=C2
Molecular Formula
C27H21Cl2NO5
Molecular Weight
510.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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