THK5351
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
Product Specifications
CAS Number
1707147-26-9
UNSPSC
12352200
Target
Tau Protein
Type
Biochemical Assay Reagents
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/THK5351.html
Purity
98.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@H](COC1=CC=C2N=C(C3=CC=C(NC)N=C3)C=CC2=C1)CF
Molecular Formula
C18H18FN3O2
Molecular Weight
327.35
References & Citations
[1]Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57 (2) :208-14.|[2]Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24 (1) :130-136.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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