PROTAC EZH2 Degrader-3

PROTAC EZH2 Degrader-3 (ZJ-20) is a potent, cell-permeable small molecule that selectively degrades EZH2 and disrupts PRC2 complex function, reducing H3K27me3 levels. It demonstrates robust anti-proliferative effects in vitro by inducing G0/G1 cell cycle arrest and apoptosis, making it a valuable chemical probe for oncology and epigenetics research.