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PROTAC SMARCA2 degrader-24

PROTAC SMARCA2 degrader-24 (Compound 34) is a potent, selective degrader of the SMARCA2 bromodomain protein, demonstrating a DC50 100-fold selectivity over SMARCA4. This tool compound is used in vitro to probe SWI/SNF chromatin remodeling complex biology and for targeted protein degradation research.

Product Specifications

CAS Number

2755761-70-5

Field of Research

Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery

Smiles

C (CN (CCC=1C=C (C (C (=O) N2[C@H] (C (N[C@@H] (C) C3=CC=C (C=C3) C=4SC=NC4C) =O) C[C@@H] (O) C2) C (C) C) ON1) C) N5C[C@]6 (N (C=7C (NC6) =NN=C (C7) C8=C (O) C=CC=C8) CC5) [H]

Molecular Formula

C45H56N10O5S

Molecular Weight

849.06

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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