KRAS G12D inhibitor 25
This small molecule inhibitor targets KRAS G12C and HSP90α with IC50 values below 0.1 μM and in the 0.1-1 μM range, respectively. It demonstrates potent anti-proliferative activity against MIA PaCa-2 and NCI-H358 cancer cell lines and induces ERBB2 degradation, making it a useful tool for oncology research in vitro.
Product Specifications
CAS Number
2768099-61-0
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C[C@H]1CN (C (=O) C2CCN (CC3=CC=C (C=C3) N4C (=NNC4=O) C5=CC (C (C) C) =C (O) C=C5O) CC2) CCC1) C6=NC (=C7C (CN (CC7) C=8C9=C (C=CC8) C=CC=C9Cl) =N6) N%10C[C@H] (CC#N) N (C (C=C) =O) CC%10
Molecular Formula
C56H62ClN11O6
Molecular Weight
1020.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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