AK-1690
AK-1690 is a potent, selective STAT6-targeting PROTAC degrader with a cellular DC50 of 1 nM. It effectively depletes STAT6 protein in both cellular assays and mouse tissues, making it a valuable chemical probe for oncology research, particularly in studying STAT6-dependent signaling pathways in cancer.
Product Specifications
CAS Number
2984505-88-4
Product Name Alternative
AK1690
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.95% (May vary between batches)
Solubility
DMSO:80 mg/mL (78.74 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (3.25 mM)
Smiles
C (#CCCCCCO[C@H]1C[C@@H] (C (=O) N2C[C@H] (OCC2) C3=CC=CC=C3) N (C ([C@@H] (NC (=O) C4=CC=5C (S4) =CC=C (C (P (=O) (O) O) (F) F) C5) [C@@] (C) (C) C) =O) C1) C6=C7C (C (=O) N (C7) C8C (=O) NC (=O) CC8) =CC=C6
Molecular Formula
C51H56F2N5O11PS
Molecular Weight
1016.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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