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Kv7.2/Kv7.3 agonist 1

Compound 16 is an orally active, small-molecule agonist of Kv7.2/Kv7.3 (KCNQ2/3) potassium channels with an in vitro EC50 of 1.03 μM. It shows in vivo efficacy, providing analgesia in mouse models of neuropathic pain, including chronic constriction injury and diabetic peripheral neuropathy.

Product Specifications

CAS Number

2315450-35-0

Field of Research

Pharmacology & Drug Discovery

Smiles

O=C (NC1=NC (OCC2=CC=C (F) C=C2) =CC=C1N) C

Molecular Formula

C14H14FN3O2

Molecular Weight

275.28

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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