Keap1-Nrf2-IN-23

Keap1-Nrf2-IN-23 (compound 56) is a potent, orally active small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction, with an IC50 of 16.0 nM and a Kd of 3.07 nM for Keap1. It is a valuable research tool for investigating the Nrf2 pathway in oxidative stress and inflammation models, both in vitro and in vivo.