Claturafenib
Claturafenib (PF-07799933) is a selective, brain-penetrant inhibitor targeting diverse BRAF mutants, effectively suppressing pERK in HT29 cells. It demonstrates preclinical antitumor efficacy in BRAF V600 and non-V600 models, supporting its investigation in oncology research, both as a monotherapy and in combination with MEK inhibitors.
Product Specifications
CAS Number
2754408-94-9
Product Name Alternative
ARRY440, ARRY-440, PF07799933, PF-07799933
Field of Research
Cell Biology, Signal Transduction
Purity
98.68% (May vary between batches)
Solubility
DMSO:80 mg/mL (163.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.73 mM)
Smiles
O=C1C2=C (N=CN1C) C=CC (NC=3C (F) =CC=C (NS (=O) (=O) N4CC (F) C4) C3Cl) =C2Cl
Molecular Formula
C18H15Cl2F2N5O3S
Molecular Weight
490.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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