PROTAC SMARCA2 degrader-30
PROTAC SMARCA2 degrader-30 (example 85) is a potent, cell-permeable small molecule that selectively degrades the SMARCA2 (BRM) protein. It demonstrates high potency with a DC50 below 100 nM in H1299 lung carcinoma cells in vitro, making it a valuable chemical probe for studying chromatin remodeling and oncology target validation.
Product Specifications
CAS Number
2408393-67-7
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1NC (=O) C (N2C3=NC=CC=C3C4=CC (=CC=C42) CN5CCC (CN (C) CCN6CCN (CC7=CC=C (C=C7) C8=CC (=NN=C8N) C=9C=CC=CC9O) CC6) CC5) CC1
Molecular Formula
C47H54N10O3
Molecular Weight
807
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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