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WS-11

WS-11 is a potent, reversible non-covalent inhibitor of both wild-type (IC50=3.9 nM) and C481S mutant (IC50=2.2 nM) BTK, stabilized by key hydrogen bonds and π-interactions with residues PHE540 and LYS430. It is a valuable chemical probe for studying B-cell signaling pathways in both cellular and animal models of autoimmune diseases and B-cell malignancies.

Product Specifications

CAS Number

2759280-09-4

Field of Research

Cardiovascular Research, Signal Transduction

Smiles

O=C1N=C (C=C1) N2CCCC (N3N=C (C=4C=CC (=CC4F) C (=O) NC5=NC=CC=C5) C=6C (=NC=NC63) N) C2

Molecular Formula

C26H22FN9O2

Molecular Weight

511.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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