YLIU-4-105-1
YLIU-4-105-1 is a potent and selective type II JAK2 inhibitor. It demonstrates robust in vivo efficacy by dose-dependently reducing splenomegaly and reticulocytosis, and it directly suppresses JAK2 signaling via inhibition of pSTAT5. This compound is a valuable research tool for investigating JAK2-driven pathologies such as myeloproliferative neoplasms in both cellular and animal models.
Product Specifications
CAS Number
2417685-83-5
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NC=1C=C (C=C (C1) C (F) (F) F) CN2CCN (CC) CC2) C=3C=CC (=C (C3) C4=NN5C=C (N=C5C=C4) NC (=O) C6CC6) C
Molecular Formula
C32H34F3N7O2
Molecular Weight
605.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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