PROTAC SMARCA2 degrader-21
PROTAC SMARCA2 degrader-21 (Compound I-5) is a potent, cell-permeable small molecule that induces targeted degradation of the SMARCA2 protein. It demonstrates high potency in A549 cells (DC50 10-50 nM) and dual degradation of SMARCA2 and SMARCA4 in MV4;11 cells. This tool compound is valuable for probing SWI/SNF chromatin remodeling complex function in cancer biology and targeted protein degradation research.
Product Specifications
CAS Number
2891464-61-0
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C (NCC=1C=CC (=CC1) C=2SC=NC2C) C3N (C (=O) C (NC (=O) C4CC5 (C4) CC (N6CCC (C7=NC (=NC=C7) N8CCN9C%10=CC (=NN=C%10NCC9C8) C=%11C=CC=CC%11O) CC6) C5) C (C) (C) C) CC (O) C3
Molecular Formula
C54H66N12O5S
Molecular Weight
995.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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