PROTAC SMARCA2/4-degrader-35
PROTAC SMARCA2/4-degrader-35 (Example 43) potently degrades SMARCA2 and SMARCA4 proteins with a DC50 below 2.5 nM. This bifunctional molecule is a valuable chemical probe for investigating chromatin remodeling and oncogenic roles of these ATPases in cancer biology, applicable in both cellular and in vivo research models.
Product Specifications
CAS Number
2933253-85-9
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=NC=2N (C=C (N2) C3=C (O) C=CC=C3) C=C1C4=CN (C[C@@H]5C[C@@H] (OC6CCN (CC7CCN (CC7) C=8C=C ([C@H] (C (=O) N9[C@H] (C (N[C@@H] (C) C%10=CC=C (C=C%10) C%11=CC=NN%11C) =O) C[C@@H] (O) C9) C (C) C) ON8) CC6) C5) N=C4
Molecular Formula
C56H69N13O6
Molecular Weight
1020.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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