Homer
Homer is a potent and selective WDR5 degrader with a DC50 of 53 nM in MV4-11 cells, acting post-translationally without affecting WDR5 mRNA. This probe is a valuable chemical tool for investigating WDR5 function in chromatin regulation and leukemia models, both in vitro and in vivo.
Product Specifications
CAS Number
2737222-94-3
Field of Research
Cell Biology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery
Purity
99.93% (May vary between batches)
Smiles
N (C (=O) C=1C (C (F) (F) F) =CC (=O) NC1) C2=C (C=CC (=C2) C3=CC=C (C (NCCCCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4) C (C) (C) C) =O) =O) C=C3) N7CCN (C) CC7
Molecular Formula
C52H60F3N9O7S
Molecular Weight
1012.15
Storage Conditions
-20°C
Notes
For research use only.
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