ZX703
ZX703 is a PROTAC molecule that induces GPX4 degradation via dual ubiquitin-proteasome and autophagy-lysosome pathways (DC50 = 0.315 μM) . This degradation triggers lipid ROS accumulation and ferroptosis, providing a research tool for studying this cell death mechanism in cancer models both in vitro and in vivo.
Product Specifications
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.72% (May vary between batches)
Smiles
CC1=C (SC=N1) C2=CC=C (C=C2) CNC (=O) [C@@H]3C[C@H] (CN3C (=O) [C@H] (C (C) (C) C) NC (=O) CCCCCCCCCOC4=CC=C (C=C4) C (C5=CC=C (C=C5) Cl) N6CCN (CC6) C (=O) C7=NOC (=C7[N+] (=O) [O-]) C) O
Molecular Formula
C54H67ClN8O9S
Molecular Weight
1039.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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