AZ 14145845
AZ 14145845 is a potent, orally bioavailable dual Mer/Axl kinase inhibitor. It demonstrates dose-dependent antitumor efficacy in Ba/F3 xenograft models and enhances survival in MC38 tumor models when combined with anti-PD1 therapy and radiation. This compound is a valuable research tool for investigating TAM kinase signaling in immuno-oncology and combination therapies.
Product Specifications
CAS Number
2830555-70-7
Smiles
N=1N=C (OC1C=2N=CC (=CC2C) C=3C (=NN (C3C) C) C) N (C) CC=4C=CC5=NC=C (C=6C=CC (=CC6) CN (C) C) N5C4
Molecular Formula
C32H35N9O
Molecular Weight
561.68
Storage Conditions
-20°C
Notes
For research use only.
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