BAY 593
BAY 593 is a potent and selective geranylgeranyltransferase-I (GGTase-I) inhibitor that blocks Rho-GTPase activation and downstream YAP1/TAZ signaling. It demonstrates dose-dependent antitumor activity in vitro (IC50: 38.4 nM in MT-1080 cells) and in vivo in xenograft models, supporting its use in cancer research, particularly for studying the Hippo pathway.
Product Specifications
CAS Number
2413020-57-0
Field of Research
Stem Cell & Developmental Biology
Smiles
O (C) C1=C ([C@H]2C3 (CCN (C ([C@] (C (F) (F) F) (OC) C4=CC=CC=C4) =O) CC3) CCNC2) C=CC=C1.Cl
Molecular Formula
C26H32ClF3N2O3
Molecular Weight
512.99
Storage Conditions
-20°C
Notes
For research use only.
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