JQ dS-4
JQ dS-4 is a PROTAC degrader of BRG1/BRM/SMARCA4, achieving complete degradation in glioma models with DC50 values from 9-390 nM. It reduces viability in H3K27M glioma, prostate, thyroid, and salivary gland cancer cell lines, supporting its investigation in oncology research for both in vitro and in vivo applications.
Product Specifications
CAS Number
2688882-69-9
Field of Research
Epigenetics & Chromatin
Smiles
O=C (NC=1C=CN=C (Cl) C1) NC=2C=CN=C (C#CC3=CC=CC (=C3) C (=O) NCCCCNC4=CC=CC=5C (=O) N (C (=O) C45) C6C (=O) NC (=O) CC6) C2
Molecular Formula
C37H31ClN8O6
Molecular Weight
719.15
Storage Conditions
-20°C
Notes
For research use only.
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