PB2

PB2 is a tris (2-carboxyethyl) phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs[1].

Product Specifications

CAS Number

914940-24-2

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pb2.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H-][B+3]([P](CCC(OC)=O)(C1=CC=CC=C1)C2=CC=CC=C2)([H-])[H-]

Molecular Formula

C16H20BO2P

Molecular Weight

286.11

References & Citations

[1]Schlieve CR, et al. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Exp Eye Res. 2006;83 (5) :1252-1259.