Tomatidine

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine activates autophagy either in mammal cells or C elegans[2].

Product Specifications

CAS Number

[77-59-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Endogenous Metabolite; JNK; NF-κB

Type

Natural Products

Related Pathways

Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Tomatidine.html

Purity

98.0

Solubility

0.1 M HCl : < 1 mg/mL|DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@]1(O[C@]2(NC[C@@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]

Molecular Formula

C27H45NO2

Molecular Weight

415.65

Precautions

H302

References & Citations

[1]Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582 (16) :2407-12.|[2]Anil Ahsan, et al. Tomatidine Protects Against Ischemic Neuronal Injury by Improving Lysosomal Function. Eur J Pharmacol. 2020 Jun 21;173280.